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小川 洋平 (Yohei Ogawa)

研究テーマ

  • トランスポゾンの同定方法の開発と種間比較
  • シングルセルATAC-seqデータを用いた視細胞タイプの種間比較解析(Joseph Corbo博士との共同研究)

Research Themes

  • Development of methods for transposon identification and interspecies comparison
  • Comparative analysis of photoreceptor cell types using single-cell ATAC-seq data (in collaboration with Dr. Joseph Corbo)

これまでの研究成果

業績（抜粋）

  1. Y. Liu, E. C. Hurley, Y. Ogawa, M. Gause, M. B. Toomey, C. A. Myers, J. C. Corbo, Avian photoreceptor homologies and the origin of double cones. Curr. Biol. 35, 2215-2227.e6 (2025).
  2. Y. Ogawa, Y. Liu, C. A. Myers, A. Morshedian, G. L. Fain, A. P. Sampath, J. C. Corbo, Conservation of cis-regulatory codes over half a billion years of evolution. bioRxiv 2024.11.13.623372 (2024).
  3. R. Arbore, S. Barbosa, J. Brejcha, Y. Ogawa, Y. Liu, M. P. J. Nicolaï, P. Pereira, S. J. Sabatino, A. Cloutier, E. S. K. Poon, C. I. Marques, P. Andrade, G. Debruyn, S. Afonso, R. Afonso, S. G. Roy, U. Abdu, R. J. Lopes, P. Mojzeš, P. Marík, S. Y. W. Sin, M. A. White, P. M. Araújo, J. C. Corbo, M. Carneiro, A molecular mechanism for bright color variation in parrots. Science 386, eadp7710 (2024).
  4. L. I. Volkov,Y. Ogawa, R. Somjee, H. E. Vedder, H. E. Powell, D. Poria, S. Meiselman, V. J. Kefalov, J. C. Corbo, Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proc. Natl. Acad. Sci. U.S.A. 121, e2402121121 (2024).
  5. Y. Ogawa, Photoreceptor differentiation mechanisms underlying cell-type homology among vertebrates. 比較生理生化学 40, 128–136 (2023). in Japanese. English translated version is available upon request.
  6. Y. Ogawa, T. Shiraki, Y. Fukada, and D. Kojima, Foxq2 determines blue cone identity in zebrafish. Science Advances 7, 1–16 (2021).
  7. Y. Ogawa and J. C. Corbo, Partitioning of gene expression among zebrafish photoreceptor subtypes. Scientific Reports 11, 17340 (2021).
  8. Y. Ogawa, T. Shiraki, Y. Asano, A. Muto, K. Kawakami, Y. Suzuki, D. Kojima, and Y. Fukada, Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish. Proc. Natl. Acad. Sci. U.S.A. 116, 4651–4660 (2019).
  9. Y. Ogawa, T. Shiraki, D. Kojima, and Y. Fukada, Homeobox transcription factor Six7 governs expression of green opsin genes in zebrafish. Proc. R. Soc. B: Biol. 282, 20150659 (2015).

Publications

  1. Y. Liu, E. C. Hurley, Y. Ogawa, M. Gause, M. B. Toomey, C. A. Myers, J. C. Corbo, Avian photoreceptor homologies and the origin of double cones. Curr. Biol. 35, 2215-2227.e6 (2025).
  2. Y. Ogawa, Y. Liu, C. A. Myers, A. Morshedian, G. L. Fain, A. P. Sampath, J. C. Corbo, Conservation of cis-regulatory codes over half a billion years of evolution. bioRxiv 2024.11.13.623372 (2024).
  3. R. Arbore, S. Barbosa, J. Brejcha, Y. Ogawa, Y. Liu, M. P. J. Nicolaï, P. Pereira, S. J. Sabatino, A. Cloutier, E. S. K. Poon, C. I. Marques, P. Andrade, G. Debruyn, S. Afonso, R. Afonso, S. G. Roy, U. Abdu, R. J. Lopes, P. Mojzeš, P. Marík, S. Y. W. Sin, M. A. White, P. M. Araújo, J. C. Corbo, M. Carneiro, A molecular mechanism for bright color variation in parrots. Science 386, eadp7710 (2024).
  4. L. I. Volkov,Y. Ogawa, R. Somjee, H. E. Vedder, H. E. Powell, D. Poria, S. Meiselman, V. J. Kefalov, J. C. Corbo, Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proc. Natl. Acad. Sci. U.S.A. 121, e2402121121 (2024).
  5. Y. Ogawa, T. Shiraki, Y. Fukada, and D. Kojima, Foxq2 determines blue cone identity in zebrafish. Science Advances 7, 1–16 (2021).
  6. Y. Ogawa and J. C. Corbo, Partitioning of gene expression among zebrafish photoreceptor subtypes. Scientific Reports 11, 17340 (2021).
  7. Y. Ogawa, T. Shiraki, Y. Asano, A. Muto, K. Kawakami, Y. Suzuki, D. Kojima, and Y. Fukada, Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish. Proc. Natl. Acad. Sci. U.S.A. 116, 4651–4660 (2019).
  8. Y. Ogawa, T. Shiraki, D. Kojima, and Y. Fukada, Homeobox transcription factor Six7 governs expression of green opsin genes in zebrafish. Proc. R. Soc. B: Biol. 282, 20150659 (2015).

経歴・職歴

  • 2025年5月 - 現在 国立遺伝学研究所, 分子生命史研究室, 特任研究員
  • 2023年9月 - 2025年4月 Washington University School of Medicine, Pathology and Immunology, Staff Scientist
  • 2018年9月 - 2023年8月 Washington University School of Medicine, Pathology and Immunology, Postdoctoral Research Associate
  • 2020年4月 - 2022年9月 独立行政法人日本学術振興会, 海外特別研究員
  • 2018年4月 - 2018年8月 東京大学, 大学院理学系研究科, 特任研究員
  • 2016年4月 - 2018年3月 独立行政法人日本学術振興会, 特別研究員
  • 2014年4月 - 2017年3月東京大学, 大学院理学系研究科大学院博士課程, 生物科学専攻
  • 2012年4月 - 2014年3月東京大学, 大学院理学系研究科, 生物化学専攻
  • 2010年4月 - 2012年3月東京大学, 理学部, 生物化学科

Career

  • 2025 May-Present, Postdoctoral Fellow
    National Institue of Genetics, Molecular Life History Laboratory, Mishima, Japan
  • 2023 Sept-2025 Apr, Staff Scientist
    Washington University School of Medicine, Department of Pathology and Immunology, St. Louis, USA
  • 2018 Sept-2023 Aug, Postdoctoral Research Associate
    Washington University School of Medicine, Department of Pathology and Immunology, St. Louis, USA
  • 2018 Apr-Aug, Postdoctoral Fellow
    University of Tokyo, Department of Biological Sciences, Tokyo, JAPAN
  • 2017 Apr-2018 Mar, Research Fellow (Postdoctoral) of Japan Society for the Promotion of Science
    University of Tokyo, Department of Biological Sciences, Tokyo, JAPAN
  • 2012-2017, Graduate student
    The University of Tokyo, Graduate School of Science, Department of Biological Sciences, Tokyo, JAPAN
  • 2008-2012, Undergraduate student
    The University of Tokyo, Faculty of Science, Department of Biophysics and Biochemistry, Tokyo, JAPAN

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