小川 洋平 (Yohei Ogawa)
ゲノムの種間比較を通じて、遺伝子制御と細胞の多様性・進化を探る研究を紹介します。研究テーマや成果、中心仮説、論文などの業績をまとめています。
This website introduces my research on gene regulation, cell diversity, and evolution through comparative genomics, along with current projects, findings, the central hypothesis, and publications.
これまでの研究成果
Previous Research
業績(抜粋)
- S. Kuraku, Y. W. Kawaguchi, T. Niwa, R. Misawa, , M. Kadota, K. Saito, W. Godo, T. Sakamoto, W. Takagi, S. Isobe, K. Shirasawa, A. Kawaguchi, Tracing genome size dynamics in sharks and rays with inclusive sequence analysis by the Squalomix Consortium. Genome Res. 36, 1708–1723 (2026).
- , Y. Liu, C. A. Myers, A. Morshedian, G. L. Fain, A. P. Sampath, J. C. Corbo, Conservation of cis-regulatory codes over half a billion years of evolution. Sci. Adv. 11, eadw7681 (2025).
- Y. Liu, E. C. Hurley, , M. Gause, M. B. Toomey, C. A. Myers, J. C. Corbo, Avian photoreceptor homologies and the origin of double cones. Curr. Biol. 35, 2215-2227.e6 (2025).
- R. Arbore, S. Barbosa, J. Brejcha, , Y. Liu, M. P. J. Nicolaï, P. Pereira, S. J. Sabatino, A. Cloutier, E. S. K. Poon, C. I. Marques, P. Andrade, G. Debruyn, S. Afonso, R. Afonso, S. G. Roy, U. Abdu, R. J. Lopes, P. Mojzeš, P. Marík, S. Y. W. Sin, M. A. White, P. M. Araújo, J. C. Corbo, M. Carneiro, A molecular mechanism for bright color variation in parrots. Science 386, eadp7710 (2024).
- L. I. Volkov,, R. Somjee, H. E. Vedder, H. E. Powell, D. Poria, S. Meiselman, V. J. Kefalov, J. C. Corbo, Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proc. Natl. Acad. Sci. U.S.A. 121, e2402121121 (2024).
- , Photoreceptor differentiation mechanisms underlying cell-type homology among vertebrates. 比較生理生化学 40, 128–136 (2023). in Japanese. English translated version is available upon request.
- , T. Shiraki, Y. Fukada, and D. Kojima, Foxq2 determines blue cone identity in zebrafish. Science Advances 7, 1–16 (2021).
- and J. C. Corbo, Partitioning of gene expression among zebrafish photoreceptor subtypes. Scientific Reports 11, 17340 (2021).
- , T. Shiraki, Y. Asano, A. Muto, K. Kawakami, Y. Suzuki, D. Kojima, and Y. Fukada, Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish. Proc. Natl. Acad. Sci. U.S.A. 116, 4651–4660 (2019).
- , T. Shiraki, D. Kojima, and Y. Fukada, Homeobox transcription factor Six7 governs expression of green opsin genes in zebrafish. Proc. R. Soc. B: Biol. 282, 20150659 (2015).
Selected Publications
- S. Kuraku, Y. W. Kawaguchi, T. Niwa, R. Misawa, , M. Kadota, K. Saito, W. Godo, T. Sakamoto, W. Takagi, S. Isobe, K. Shirasawa, A. Kawaguchi, Tracing genome size dynamics in sharks and rays with inclusive sequence analysis by the Squalomix Consortium. Genome Res. 36, 1708–1723 (2026).
- , Y. Liu, C. A. Myers, A. Morshedian, G. L. Fain, A. P. Sampath, J. C. Corbo, Conservation of cis-regulatory codes over half a billion years of evolution. Sci. Adv. 11, eadw7681 (2025).
- Y. Liu, E. C. Hurley, , M. Gause, M. B. Toomey, C. A. Myers, J. C. Corbo, Avian photoreceptor homologies and the origin of double cones. Curr. Biol. 35, 2215-2227.e6 (2025).
- R. Arbore, S. Barbosa, J. Brejcha, , Y. Liu, M. P. J. Nicolaï, P. Pereira, S. J. Sabatino, A. Cloutier, E. S. K. Poon, C. I. Marques, P. Andrade, G. Debruyn, S. Afonso, R. Afonso, S. G. Roy, U. Abdu, R. J. Lopes, P. Mojzeš, P. Marík, S. Y. W. Sin, M. A. White, P. M. Araújo, J. C. Corbo, M. Carneiro, A molecular mechanism for bright color variation in parrots. Science 386, eadp7710 (2024).
- L. I. Volkov,, R. Somjee, H. E. Vedder, H. E. Powell, D. Poria, S. Meiselman, V. J. Kefalov, J. C. Corbo, Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proc. Natl. Acad. Sci. U.S.A. 121, e2402121121 (2024).
- , T. Shiraki, Y. Fukada, and D. Kojima, Foxq2 determines blue cone identity in zebrafish. Science Advances 7, 1–16 (2021).
- and J. C. Corbo, Partitioning of gene expression among zebrafish photoreceptor subtypes. Scientific Reports 11, 17340 (2021).
- , T. Shiraki, Y. Asano, A. Muto, K. Kawakami, Y. Suzuki, D. Kojima, and Y. Fukada, Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish. Proc. Natl. Acad. Sci. U.S.A. 116, 4651–4660 (2019).
- , T. Shiraki, D. Kojima, and Y. Fukada, Homeobox transcription factor Six7 governs expression of green opsin genes in zebrafish. Proc. R. Soc. B: Biol. 282, 20150659 (2015).
書籍
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小川洋平,
5億年の進化を経ても保たれる細胞型制御.
実験医学 44(8),2026年5月号(羊土社).連載「カレントトピックス」への寄稿.
脊椎動物6種の網膜を比較した研究を紹介しています。DNA配列が大きく変化しても、細胞の性質を支える遺伝子発現制御の仕組みが、5億年以上にわたってどのように保たれてきたのかを解説します。
Books
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Y. Ogawa,
Conservation of cis-regulatory codes over half a billion years of evolution.
Jikken Igaku 44(8), May 2026 (Yodosha). Contributed article in “Current Topics” (in Japanese).
This commentary introduces our comparison of retinal cells across six vertebrate species. It explains how gene regulatory rules underlying cell identity have persisted for more than 500 million years despite extensive changes in DNA sequence.
経歴・職歴
- 2025年11月 - 現在 国立遺伝学研究所, 分子生命史研究室, 特任助教
- 2025年5月 - 2025年10月 国立遺伝学研究所, 分子生命史研究室, 特任研究員
- 2023年9月 - 2025年4月 Washington University School of Medicine, Pathology and Immunology, Staff Scientist
- 2018年9月 - 2023年8月 Washington University School of Medicine, Pathology and Immunology, Postdoctoral Research Associate
- 2020年4月 - 2022年9月 独立行政法人日本学術振興会, 海外特別研究員
- 2018年4月 - 2018年8月 東京大学, 大学院理学系研究科, 特任研究員
- 2016年4月 - 2018年3月 独立行政法人日本学術振興会, 特別研究員
- 2014年4月 - 2017年3月東京大学, 大学院理学系研究科大学院博士課程, 生物科学専攻
- 2012年4月 - 2014年3月東京大学, 大学院理学系研究科, 生物化学専攻
- 2010年4月 - 2012年3月東京大学, 理学部, 生物化学科
Career
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2025 Nov-Present, Project Assistant Professor
National Institue of Genetics, Molecular Life History Laboratory, Mishima, Japan -
2025 May-Oct, Project Researcher
National Institue of Genetics, Molecular Life History Laboratory, Mishima, Japan -
2023 Sept-2025 Apr, Staff Scientist
Washington University School of Medicine, Department of Pathology and Immunology, St. Louis, USA -
2018 Sept-2023 Aug, Postdoctoral Research Associate
Washington University School of Medicine, Department of Pathology and Immunology, St. Louis, USA -
2018 Apr-Aug, Postdoctoral Fellow
University of Tokyo, Department of Biological Sciences, Tokyo, JAPAN -
2017 Apr-2018 Mar, Research Fellow (Postdoctoral) of Japan Society for the Promotion of Science
University of Tokyo, Department of Biological Sciences, Tokyo, JAPAN -
2012-2017, Graduate student
The University of Tokyo, Graduate School of Science, Department of Biological Sciences, Tokyo, JAPAN -
2008-2012, Undergraduate student
The University of Tokyo, Faculty of Science, Department of Biophysics and Biochemistry, Tokyo, JAPAN
受賞
- 2026年8月 第8回日本光生物学協会奨励賞(日本光生物学協会)
- 2022年11月 第31回吉田奨励賞(日本比較生理生化学会)
Awards
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2026 Aug, 8th Young Scientist Award
Photobiology Association of Japan -
2022 Nov, 31st Yoshida Prize for Young Researchers
The Japanese Society for Comparative Physiology and Biochemistry
連絡先
お問い合わせは以下の方法でお願いします:
- X: @YoheyOgawa
- BlueSky: bsky.app/profile/yohey-ogawa.bsky.social
- Email: yohei.ogawa(アットマーク)nig.ac.jp
Contact
You can reach me through the following methods:
- X: @YoheyOgawa
- BlueSky: bsky.app/profile/yohey-ogawa.bsky.social
- Email: yohei.ogawa(アットマーク)nig.ac.jp
外部リンク
- Researchmap: researchmap.jp/ogativity
- Researchgate: researchgate.net/profile/Yohey-Ogawa-2
- Google Scholar: scholar.google.com/citations?user=Yohey-Ogawa
- ORCID: orcid.org/0000-0001-9031-4393
External Links
- Researchmap: researchmap.jp/ogativity
- Researchgate: researchgate.net/profile/Yohey-Ogawa-2
- Google Scholar: scholar.google.com/citations?user=Yohey-Ogawa
- ORCID: orcid.org/0000-0001-9031-4393